医学
无氧运动
麻醉
体外循环
夹紧
谷氨酸受体
心脏病学
新陈代谢
复苏
能量代谢
内科学
生理学
机械工程
工程类
受体
作者
Eliot Rosenkranz,Fumiyuki Okamoto,Gerald D. Buckberg,Jakob Vinten-Johansen,John Robertson,Helen I. Bugyi
标识
DOI:10.1016/s0022-5223(19)38328-x
摘要
Cold blood cardioplegic techniques are limited in their ability to protect energy-depleted hearts during aortic clamping. This study extends our previous observations on the benefits of amino acid (L-glutamate) enrichment of blood cardioplegic solutions as well as the added metabolic benefits of normothermic induction of cardioplegic arrest to increase the rate of repair of energy-depleted hearts. The results demonstrate that L-glutamate enrichment of blood cardioplegic solutions significantly improves metabolic recovery (greater oxygen consumption, better anaerobic metabolism) and ventricular performance. Normothermic induction of glutamate-enriched cardioplegia allowed complete recovery of myocardial metabolism and function compared to cold blood cardioplegic technique and may be used as a form of "active resuscitation" of energy-depleted hearts.
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