Objective To investigate the chinese traditional medicine toxic and influence factor.Methods Toxic and its strength and weakness have been absolute and related to factors(medicine variety.origion,processing drugs,boilding method and regimen and compatibity and dosage and medication time etc).Results Through long-term practice,traditional chinese medicine has the methods of curing disease in combat poison and poison and it's safer to take the chinese traditional medicine than Western medicine.Conclusion It will help improve Chinese Traditional medicine curative effect and reduce toxic side effect by avoiding fore-mentioned influence factors in work and research.