The Effects of Topical Sildenafil on Wound Healing in Rat

西地那非 伤口愈合 医学 一氧化氮 成纤维细胞 药理学 外科 内科学 体外 化学 生物化学
作者
Akram Jamshidzadeh,Negar Azarpira
出处
期刊:Iranian Journal of Pharmaceutical Sciences 卷期号:7 (1): 43-48 被引量:2
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摘要

Nitric oxide (NO) is an important molecule synthesized during wound repair. S tudies have reported the use of NO donors on cutaneous wound repair, but their effects in different phases of healing are not elucidated. The aim of this work was to investigate the effects of topical sildenafil on wounds in rats. Sildenafil (25 mg) was topically applied once daily on wound in treatment groups. On days, 7, 14 and 21 of lesion, five animals in each group were randomly selected and sacrificed and h istological properties were evaluated. Our results showed the wound area contracted to 15% of the original size by day 7 post-wounding in treated group. Whereas control rats showed significantly delayed wound healing. The wound area contracted to 26% of the original size by day 14 post-wounding and to 46% by day 21 post-wounding. Also sildenafil cream caused more fibroblast and macrophage migration, increased vascularization, collagen regeneration, and epithelialization. This study indicates that sildenafil cream augments the wound healing process and may be of clinical benefit. Key wor ds: Nitric oxide;Sildenafil cream; Wound healing. Received: July 10, 2010; Accepted: September 18, 2010.
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