Efficacy of Sertraline Combine with Shumian Capsule in the Depression of Dyssomnia

OBJECTIVE:To observe the efficacy and safety of sertraline combined with Shumian capsule for depression of dyssomnia.METHODS:86 patients with depression were randomly assigned to receive sertraline alone(single group) or in combination with Shumian capsule(combined group) for 8 weeks.Clinical effectiveness was evaluated using HAMD and PSQI,and TESS was used to assess the adverse effects.RESULTS:After treatment for 8 weeks,the total effective rate was 88.2% for combined group and 85.7% for single group(P0.05).The HAMD and PSQI scores in combined group are lower than in single group(P0.01),and the difference in adverse drug reactions was not significant in 2 groups.CONCLUSION:Sertraline combined with Shumian Capsule showed better efficacy for the depression of dyssomnia yet without increasing adverse dffdcts as compared with Sertraline alone.