化学
双功能
级联
部分
非对映体
产量(工程)
分子内力
亲核加成
亲核细胞
组合化学
级联反应
催化作用
有机化学
色谱法
冶金
材料科学
作者
Lei Mo,Linlin Wu,Shaozhong Wang,Zhu-Jun Yao
出处
期刊:Organic Letters
[American Chemical Society]
日期:2015-06-22
卷期号:17 (13): 3314-3317
被引量:5
标识
DOI:10.1021/acs.orglett.5b01532
摘要
A highly efficient catalyst-free cascade reaction of air-stable isochromenylium tetrafluoroborates and bifunctional styrenes containing a 1,3-diketone moiety has been developed, affording the corresponding single diastereomeric ocatahydrophenanthrene derivatives (21 examples, up to 86% yield). A cascade process of [4 + 2]-cyclization and subsequent intramolecular nucleophilic addition is proposed to generate the three new C-C bonds diastereoselectively in the reactions.
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