This systematic review aimed to analyze the detailed mechanisms of global groundwater contaminant transport, the distinct hydroclimatic impacts of intensive abstraction activities and international regulatory frameworks required for sustainable aquifer management. Utilizing the evidence-based PRISMA reporting framework model, metadata were meticulously selected and synthesized across multiple primary academic databases, specifically including PubMed, ScienceDirect and Google Scholar respectively. The primary outcome revealed that exponential anthropogenic advancements continuously introduce diverse organic, chemical and microbial pollutants into subsurface aquatic environments. Natural hydrodynamic processes of advection and dispersion govern pollutant migration, which becomes severely accelerated when escalated water abstraction lowers localized hydrostatic pressure and collapses protective potentiometric barriers within confined aquifers. To counteract this widespread deterioration, a comparative evaluation of remediation strategies indicated that passive in-situ treatments offer much more economical, site-specific environmental advantages over conventional above-ground ex-situ techniques. Furthermore, while historical transboundary governance relied primarily on non-binding instruments like UN Resolution 63/124, recent frameworks such as UNGA Resolution 77/111 placed a significantly stronger emphasis on unified operational governance, shared joint monitoring platforms and climate-adaptive management for shared transboundary systems. Conclusively, achieving groundwater sustainability requires integrating localized wellhead engineering with robust municipal legislation. Future research should leverage advanced collaborative platforms to empirically evaluate the long-term impacts of climate change uncertainties on transboundary aquifer flow dynamics.