Copper sulfide nanoparticles coated with Fe-EGCG networks for targeted MR imaging and chemo/photothermal/chemodynamic synergetic therapy of tumors

. Notably, EGCG and NIR laser irradiation could enhance Fe-mediated Fenton reaction efficiency, increasing hydroxyl radical (˙OH) production and potentiating chemodynamic therapy efficacy. Through effectively generating reactive oxygen species (ROS), consuming glutathione (GSH), accumulating lipid peroxidation (LPO), and promoting cancer cell apoptosis under laser irradiation, the FA-CuS PENs@Fe-EGCG nanocomposites could exert superior tumor suppression efficacy in the 4T1 xenograft mice model by targeted chemo/photothermal/chemodynamic synergetic therapy. This work presents a succinct design of advanced nanocomposites incorporating CuS NPs and MPNs, offering a promising strategy for tumor theranostics.