二肽
等甾体
化学
立体化学
组合化学
氨基酸
生物化学
作者
Bengt Erik Haug,Daniel H. Rich
出处
期刊:Organic Letters
[American Chemical Society]
日期:2004-11-12
卷期号:6 (25): 4783-4786
被引量:24
摘要
The protected Gln-Phe hydroxyethylene dipeptide isostere 1 was synthesized as a precursor for preparation of potential inhibitors of Botulinum neurotoxin B metalloprotease. The method allows for the synthesis of additional hydroxyethylene dipeptide isosteres such as 2 with functionalized P1 side chains. The isosteres prepared were coupled with a dipeptide to produce protected pseudotetrapeptide derivatives.
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