OP21.07: Correlation between placental pathology and angiogenetic factors

To evaluate the correlation between placental pathology classified as “jelly like” and spherically thick placenta, Doppler parameters and angiogenetic factors sFlt-1and PLGF and their ratio. All cases with sonomorhological pattern of “jelly like” or spherically thick placenta of the last 10 years and with known angiogentic agents were included. Data of umbilical (UA) and uterine artery (utA) Doppler and clinical data were investigated and correlated with angiogenetic factors. Statistical analysis was done with Fisher-s exact test, nonparametric correlation and column statistics. 24 cases with “jelly like” (group 1) and 29 with spherically thick placenta (group 2) were included. Both groups were equal in most parameters, especially in gestational age at inclusion and at birth, Doppler values, preterm deliveries because of pre-eclampsia ± IUGR/HELLP or IUGR, birthweight and placenta weight. Significant higher values of UA PI > 95th centile (p 0.04), utA PI (p 0.03) and sFlit-1 (p 0.04) were found in group 1. The sFlt-1/PlGF ratio was > 85 in 22/24 cases (92%) in group 1 and in 24/29 (83 %) in group 2. A significant correlation was seen between UA PI, PlGF (r=0.60; p 0.004) and ratio (r= 0.38; p 0.05), utA PI, PLGF (r=0.47; p 0.03); birthweight, PLGF (r=0.72, p 0.01) and placenta weight, PlGF (r= 0.74; p 0.001) and ratio (r=0.49; p 0.02) in group 1 and between UA PI, PlGF (r=0.49; p 0.01) and ratio (r= 0.49; p 0.007), utA PI, PlGF (r= 0.55; p 0.004), birthweight, PlGF (r= 61; p 0.002) and ratio (r= 0.55; p 0.003) and placenta weight, PlGF (r= 0.65; p 0.001) and ratio (r= 0.55; p 0.005) in group 2. Both placenta pathologies, in particular “jelly like” placenta, are sonomorphologic signs for a severe angiogenetic disturbance and correlated with changes in fetomaternal hemodynamic and outcome. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.