Toll样受体9
CpG站点
DNA
先天免疫系统
TLR9型
胞嘧啶
Toll样受体
鸟嘌呤
生物
细胞生物学
DNA甲基化
受体
分子生物学
化学
基因
遗传学
核苷酸
基因表达
作者
Hanako Ishida,Umeharu Ohto,Takuma Shibata,Kensuke Miyake,Toshiyuki Shimizu
出处
期刊:FEBS Letters
[Wiley]
日期:2018-07-13
卷期号:592 (15): 2636-2646
被引量:11
标识
DOI:10.1002/1873-3468.13176
摘要
Single‐stranded DNA containing unmethylated cytosine‐phosphate‐guanine (CpG) motifs derived from microorganisms are recognized by Toll‐like receptor ( TLR ) 9 and activate an innate immune response. TLR 9 has two DNA ‐binding sites for CpG DNA and DNA containing cytosine at the second position from the 5′‐end; both are required for efficient TLR 9 activation in most vertebrate species. However, mouse TLR 9 can be dimerized by CpG DNA only, although the underlying mechanism remains elusive. Here, we report the crystal structure of mouse TLR 9 complexed with both DNA s. Although most TLR 9‐CpG DNA interactions are conserved among species, some are unique to mice and involved in species‐specificity. These findings provide the structural basis for how mouse TLR 9 dimerizes efficiently in response to CpG DNA to activate innate immunity.
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