疾病
神经科学
胰岛素抵抗
翻译(生物学)
胰岛素受体
阿尔茨海默病
胰岛素
生物信息学
心理学
生物
医学
遗传学
内分泌学
病理
基因
信使核糖核酸
作者
Natalia de M. Lyra e Silva,Rafaella Araújo Gonçalves,Susan E. Boehnke,Letícia Forny-Germano,Douglas P. Munoz,Fernanda G. De Felice
标识
DOI:10.1016/j.expneurol.2019.03.016
摘要
Alzheimer's disease (AD) is a devastating neurodegenerative disease affecting millions of people worldwide. AD is characterized by a profound impairment of higher cognitive functions and still lacks any effective disease-modifying treatment. Defective insulin signaling has been implicated in AD pathophysiology, but the mechanisms underlying this process are not fully understood. Here, we review the molecular mechanisms underlying defective brain insulin signaling in rodent models of AD, and in a non-human primate (NHP) model of the disease that recapitulates features observed in AD brains. We further highlight similarities between the NHP and human brains and discuss why NHP models of AD are important to understand disease mechanisms and to improve the translation of effective therapies to humans. We discuss how studies using different animal models have contributed to elucidate the link between insulin resistance and AD.
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