肌红蛋白
医学
肌酸激酶
心脏病学
肌钙蛋白
心肌梗塞
内科学
肌钙蛋白T
心脏标志物
肌钙蛋白I
心肌梗死诊断
肌酸
生物化学
化学
作者
Alexander Chiu,W K Chan,Shuanghou Cheng,C K Leung,C H Choi
标识
DOI:10.1093/qjmed/92.12.711
摘要
Myoglobin, creatine kinase-MB (CKMB) mass concentration and troponin-I are newer biochemical markers for the diagnosis of acute myocardial infarction (AMI). We conducted a prospective study to formulate a model for the collective interpretation of these three markers in the diagnosis of AMI. Eighty-seven patients with AMI had serial serum samples taken to establish the time-frame sensitivity of individual markers. None of the markers had a good sensitivity within the first 4 h of infarction. Myoglobin and CKMB (mass) had sensitivities of 92.3% and 96.2%, respectively, at 4–8 h post infarct. CKMB (mass) and troponin-I had sensitivities >92% at 8–24 h. Troponin-I maintained sensitivity >93% until 72 h. A guideline was formulated based on the results. Our data suggest that troponin-I, myoglobin and CKMB (mass) yield satisfactory diagnostic sensitivity when used with reference to specific time frames. The combined use of these markers can provide valuable information for clinicians in managing AMI patients.
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