化学
敌手
立体化学
化学合成
体外
生物化学
受体
作者
Jeffrey P. Whitten,D. Muench,Rowena V. Cube,P. L. Nyce,Bruce M. Baron,Ian A. McDonald
标识
DOI:10.1016/s0960-894x(01)81102-1
摘要
The synthesis of the conformationally-restricted β-ketophosphonic acid, 3(S)-phosphonoacetyl-2(R)-piperidinecarboxylic acid (4) is described. This compound is a competitive, glutamate antagonist (IC50 = 40 nM vs [3H]CPP) of the NMDA receptor complex.
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