锐钛矿
纳米点
无定形固体
材料科学
化学工程
纳米技术
化学
结晶学
光催化
催化作用
工程类
有机化学
作者
Yi Hong,Mengfei Yu,Jun Lin,Kui Cheng,Wenjian Weng,Huiming Wang
标识
DOI:10.1016/j.colsurfb.2014.08.030
摘要
In this study, we investigated the differences between amorphous and anatase TiO2 at the biomolecular level which could explain differences in the osteoblast response on these surfaces. The number of surface hydroxyl groups in the TiOHT form on amorphous and anatase TiO2 was found to be the most important factor, resulting in adsorption of bovine serum albumin as a monolayer on amorphous TiO2 nanodots but as a multilayer on anatase TiO2 nanodots. The reason for this is that the presence of more TiOHT groups on amorphous TiO2 nanodots attracts more -NH3+ groups on BSA molecules, causing the conformation of surface-bound BSA molecules to differ from those adsorbed on anatase TiO2 nanodots. Fibronectin which is subsequently adsorbed on anatase TiO2 nanodots then retains a more active conformation for osteoblast adhesion and mineralization.
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