细胞周期蛋白D1
生物
细胞周期蛋白D
细胞周期蛋白A2
视网膜母细胞瘤蛋白
细胞周期蛋白
细胞周期蛋白B
癌症研究
细胞生物学
分子生物学
雄激素受体
细胞周期
遗传学
基因
癌症
前列腺癌
作者
Anne T. Reutens,Maofu Fu,Chenguang Wang,Chris Albanese,Michael J. McPhaul,Zijie Sun,Steven P. Balk,Olli A. Jänne,Jorma J. Palvimo,Richard G. Pestell
标识
DOI:10.1210/mend.15.5.0641
摘要
The androgen receptor (AR) is a ligand-regulated member of the nuclear receptor superfamily. The cyclin D1 gene product, which encodes the regulatory subunit of holoenzymes that phosphorylate the retinoblastoma protein (pRB), promotes cellular proliferation and inhibits cellular differentiation in several different cell types. Herein the cyclin D1 gene product inhibited ligand-induced AR- enhancer function through a pRB-independent mechanism requiring the cyclin D1 carboxyl terminus. The histone acetyltransferase activity of P/CAF (p300/CBP associated factor) rescued cyclin D1-mediated AR trans-repression. Cyclin D1 and the AR both bound to similar domains of P/CAF, and cyclin D1 displaced binding of the AR to P/CAF in vitro. These studies suggest cyclin D1 binding to the AR may repress ligand-dependent AR activity by directly competing for P/CAF binding.
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