Application of Ugi Consecutive Protocol in the Synthesis of a Peptoid Analogue of Verticilide

Peptoids are non-natural molecules being capable to mimic the natural structure of peptides. These mimetics are based on oligo-N-substituted glycine backbones which exhibit proteolytic stability and wide range of biological activities. Verticilide 1 is a cyclic depsipeptide that exhibits insecticidal activity and was isolated from the culture broth of Verticilium sp. FK-1033 (Figure 1). In order to apply the microwave-assisted synthesis of peptoids via Ugi reactions developed by our groups, we decided to perform the synthesis of a peptoid analogue of Verticilide (Figure 1).