Novel, Stereoselective and Stereospecific Synthesis of Allenylphosphonates and Related Compounds via Palladium‐Catalyzed Propargylic Substitution

Abstract We have developed a novel method for the synthesis of allenylphosphonates and related compounds based on a palladium(0)‐catalyzed reaction of propargylic derivatives with H‐phosphonate, H‐phosphonothioate, H‐phosphonoselenoate, and H‐phosphinate esters. The reaction is stereoselective and stereospecific, and provides a convenient entry to a vast array of allenylphosphonates and their analogues with diverse substitution patterns in the allenic moiety and at the phosphorus center. Some mechanistic aspects of this new reaction were also investigated.