丝氨酸
生物
癌细胞
生物化学
新陈代谢
蛋氨酸
细胞外
癌症
生物合成
细胞生长
细胞生物学
氨基酸
酶
遗传学
作者
Alice C. Newman,Oliver D.K. Maddocks
标识
DOI:10.1016/j.tcb.2017.05.001
摘要
Folate metabolism functions to supply one-carbon units that are vital for a range of biochemical reactions. Cancer cells can utilise serine as a major source of one-carbon units, rendering them dependent upon extracellular serine uptake or de novo serine synthesis for maximal growth and proliferation. One-carbon units are required for the production of critical cellular components, such as nucleotides, which enable cancer cells to maintain high proliferate rates. Of recent interest, one-carbon metabolism contributes to the biosynthesis and recycling of functional metabolites, such as ATP, S-adenosyl-methionine (SAM), and NAD(P)H, with important downstream consequences for cancer cell survival. In this review, we describe recent advances in our understanding of the importance of one-carbon metabolism in cancer, focussing upon the routes through which cancer cells obtain and use one-carbon units.
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