固体脂质纳米粒
Zeta电位
聚乙烯醇
粒径
体内
化学
色谱法
生物利用度
均质化(气候)
药物输送
毒品携带者
药理学
纳米颗粒
材料科学
纳米技术
医学
有机化学
生物技术
生物
物理化学
生物多样性
生态学
作者
Yun Zhao,Yuexing Chang,Xiaoyun Hu,Chunyu Liu,Li-Hui Quan,Yong-Hong Liao
标识
DOI:10.1016/j.ijpharm.2016.11.046
摘要
The objective of this study was to prepare solid lipid nanoparticles (SLNs) for sustained pulmonary delivery of Yuxingcao essential oil (YEO). Three YEO loaded SLNs (SLN-200, SLN-400 and SLN-800) with different particle size were prepared and separated following a high-shear homogenization technique using Compritol 888 ATO as lipid and polyvinyl alcohol as an emulsifier. The particle size, zeta potential, drug encapsulation efficiency and drug loading of the SLNs were determined to be between 171 and 812 nm, −17.1 and −19.3 mV, between 76.6 and 90.2% and between 2.34 and 3.12%, respectively whereas the in vitro release data showed that the SLNs led to sustained drug release up to 48 h. In addition, the SLN suspensions after nebulization conferred the fine particle fractions (<5.4 μm) of 67.4–75.8%. Following intratracheal administration to rats, YEO loaded SLNs not only prolonged pulmonary retention up to 24 h, but also increased AUC values (15.4, 18.2 and 26.3 μg/g h for SLN-200, SLN-400 and SLN-800, respectively) by 4.5-7.7 folds compared to the intratracheally dosed YEO solution and by 257–438 folds to the intravenously dosed YEO solution, respectively. The present results were the first to show that YEO loaded SLNs may sustain YEO inhalation delivery and improve local bioavailability, representing a promising inhalable carrier to attain once daily application.
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