医学
亚甲基四氢叶酸还原酶
卵圆孔未闭
内科学
经颅多普勒
心脏病学
冲程(发动机)
因素五莱顿
反常栓塞
人口
血栓性
基因突变
经皮
静脉血栓形成
血栓形成
突变
遗传学
基因
基因型
工程类
环境卫生
生物
机械工程
作者
Rodrigo Tavares Brisson,Josevânia Fulgêncio de Lima Arruda,Liene Duarte Silva,Dilermando Leal Júnio de Jesus,Viviane Flumignan Zétola,Marcia Aparecida Camacho Kauffmann Nogueira
出处
期刊:Military Medicine
[Oxford University Press]
日期:2021-05-16
卷期号:188 (3-4): e885-e889
被引量:1
标识
DOI:10.1093/milmed/usab192
摘要
We report two cases of Brazilian patients (a 22-year-old male and a 48-year-old male) with ischemic stroke, whose arterial vascular study and echocardiographic investigation did not reveal any steno-occlusive arterial disease or typical cardioembolic finding, such as atrial fibrillation or myocardial dysfunction. A transcranial Doppler ultrasound and a transesophageal echocardiogram showed a patent foramen ovale (PFO), and the laboratory screening for coagulation abnormalities showed heterozygosity for MTHFR C677T and A1298C in one of the patients and heterozygosity for factor V Leiden gene mutations in the other patient. The significance of the association of PFO with Methylenetetrahydrofolate (MTHFR) C677T and A1298C variants or factor V Leiden mutation is discussed as a possible cause of ischemic stroke through paradoxical embolism from a venous source. There is a high prevalence of these two mentioned conditions in the general population, so we discuss two cases in which indication for anticoagulant therapy or percutaneous closure of PFO prevails.
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