抵抗性
生物
基因组
盐度
微生物群
丰度(生态学)
生态系统
生态学
相对物种丰度
微生物种群生物学
抗生素耐药性
细菌
微生物学
抗生素
生物信息学
基因
生物化学
整合子
遗传学
作者
Haowen Liang,Fan Wang,Rong Mu,Jin Huang,Renxin Zhao,Xiaoyan Li,Ke Yu,Bing Luo
标识
DOI:10.1016/j.scitotenv.2021.148262
摘要
Although antimicrobial resistance genes (ARGs) in dozens of environments have been well documented, the distribution of ARGs in salt lake ecosystems has been less intensively investigated. In this study, the broad-spectrum ARG profiles, microbial community composition and the comprehensive associations between microbiome and antimicrobial resistome in four salt lakes were investigated using a metagenomic approach. A total of 175 ARG subtypes affiliated with 19 ARG types were detected, and ARGs conferring resistance to multidrug, bacitracin, and macrolide-lincosamide-streptogramin (MLS) accounted for 71.2% of the total ARG abundance. However, the abundance of ARGs significantly decreased with the increasing salinity in the lakes. Both ARG profiles and microbial community structure presented remarkable discrepancies in different lakes, as well as in different sample types. Microbes such as genera Azoarcus, Aeromonas, Pseudomonas, and Kocuria, significantly co-occurred with multiple ARGs, indicating that these bacteria are potential ARG hosts in salt lake ecosystems. Collectively, this work provides new insights into the occurrence and distribution of ARGs in salt lake ecosystems.
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