互连性
自愈水凝胶
棒
复合材料
材料科学
球体
各向异性
化学
粒子(生态学)
高分子化学
病理
替代医学
体外
人工智能
地质学
物理
海洋学
医学
量子力学
生物化学
计算机科学
作者
Taimoor H. Qazi,Jingyu Wu,Victoria G. Muir,Shoshana Weintraub,Sarah E. Gullbrand,Daeyeon Lee,David Issadore,Jason A. Burdick
标识
DOI:10.1101/2021.09.23.461542
摘要
Abstract Granular hydrogels have emerged as a new class of injectable and porous biomaterials that improve integration with host tissue when compared to solid hydrogels. Granular hydrogels are typically prepared using spherical particles and this study considers whether particle shape (i.e., isotropic spheres versus anisotropic rods) influences granular hydrogel properties and cellular invasion. Simulations predict that anisotropic rods influence pore shape and interconnectivity, as well as bead transport through granular assemblies. Photocrosslinkable norbornene-modified hyaluronic acid is used to produce spherical and rod-shaped particles using microfluidic droplet generators and formed into shear-thinning and self-healing granular hydrogels at low and high particle packing. Rod-shaped particles form granular hydrogels that have anisotropic and interconnected pores, with pore number and size, storage moduli, and extrusion forces influenced by particle shape and packing. Robust in vitro sprouting of endothelial cells from embedded cellular spheroids is observed with rod-shaped particles, including higher sprouting densities and sprout lengths when compared to hydrogels with spherical particles. Cellular invasion into granular hydrogels when injected subcutaneously in vivo is significantly greater with rod-shaped particles, whereas a gradient of cellularity is observed with spherical particles. Overall, this work demonstrates potentially superior functional properties of granular hydrogels with rod-shaped particles for tissue repair.
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