恶性疟原虫
抗体
免疫球蛋白G
脱颗粒
生物
病毒学
调理素
免疫学
免疫
疟疾
抗体依赖性细胞介导的细胞毒性
Fc受体
免疫
吞噬作用
免疫系统
受体
单克隆抗体
生物化学
作者
Mads Delbo Larsen,Mary Lopez-Perez,Emmanuel K. Dickson,Paulina Ampomah,Nicaise Tuikue Ndam,Jan Nouta,Carolien A. M. Koeleman,Agnes L. Hipgrave Ederveen,Benjamin Mordmüller,Ali Salanti,Morten Nielsen,Achille Massougbodji,C. Ellen van der Schoot,Michael F. Ofori,Manfred Wuhrer,Lars Hviid,Gestur Vidarsson
标识
DOI:10.1038/s41467-021-26118-w
摘要
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family members mediate receptor- and tissue-specific sequestration of infected erythrocytes (IEs) in malaria. Antibody responses are a central component of naturally acquired malaria immunity. PfEMP1-specific IgG likely protects by inhibiting IE sequestration and through IgG-Fc Receptor (FcγR) mediated phagocytosis and killing of antibody-opsonized IEs. The affinity of afucosylated IgG to FcγRIIIa is up to 40-fold higher than fucosylated IgG, resulting in enhanced antibody-dependent cellular cytotoxicity. Most IgG in plasma is fully fucosylated, but afucosylated IgG is elicited in response to enveloped viruses and to paternal alloantigens during pregnancy. Here we show that naturally acquired PfEMP1-specific IgG is strongly afucosylated in a stable and exposure-dependent manner, and efficiently induces FcγRIIIa-dependent natural killer (NK) cell degranulation. In contrast, immunization with a subunit PfEMP1 (VAR2CSA) vaccine results in fully fucosylated specific IgG. These results have implications for understanding protective natural- and vaccine-induced immunity to malaria.
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