补体系统
补语(音乐)
癌症研究
免疫疗法
癌症
医学
生物
免疫学
抗体
内科学
表型
生物化学
基因
互补
作者
Marie V. Daugan,Margot Revel,Jules Russick,Marie‐Agnès Dragon‐Durey,Christine Gaboriaud,Tania Robe-Rybkine,Victoria Poillerat,Anne Grünenwald,Guillaume Lacroix,Antoine Bougoüin,Maxime Meylan,Virginie Verkarre,Stéphane Oudard,Arnaud Méjean,Yann Vano,Géraldine Perkins,Pierre Validire,Xavier Cathelineau,Rafael Sanchez‐Salas,Diane Damotte
标识
DOI:10.1158/2326-6066.cir-20-0532
摘要
C1s is shown to drive renal cell carcinoma progression by local complement activation and complement cascade–unrelated, intracellular, noncanonical functions. This modulates the tumor microenvironment by impacting tumor cell proliferation, survival, and interaction with T cells.
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