化学
烯酮
异构化
磺胺基
芳基
光催化
反应性(心理学)
吡唑
组合化学
催化作用
迈克尔反应
加合物
立体选择性
光化学
有机化学
药物化学
光催化
病理
替代医学
医学
烷基
作者
Alberto Luridiana,Angelo Frongia,Mariano Andrea Scorciapino,Giuliano Malloci,Barbara Manconi,Simone Serrao,Pier Carlo Ricci,Francesco Secci
标识
DOI:10.1002/adsc.202100996
摘要
Abstract A synthetically useful Z ‐selective cascade formal thiyl radical addition, 1,3‐double bond isomerization, oxygen trapping reaction, can be promoted by Eosin B under visible light, leading to the construction of 2‐aryl‐ and alkylthio enone derivatives in good yields. An accurate study on the reactivity of different thiols and the screening of the reaction conditions, allowed us to extend this reaction to a large number of substrates, showing a good functional groups tolerance while highlighting the limitations of this procedure. Background experiments and mechanistic studies were also. performed to rationalize this cascade process. The usefulness of this methodology was finally demonstrated via the transformation of a series of α‐sulfanyl‐enone adducts through selected oxidation reactions, stereoselective synthesis of cyclopropyl ketones, indanones, and pyrazole compounds. magnified image
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