医学
髓系白血病
重症监护医学
靶向治疗
不利影响
造血干细胞
肿瘤科
干细胞
内科学
造血
癌症
遗传学
生物
作者
LaQuita M Jones,Katherine Tarlock,Todd M. Cooper
出处
期刊:Pediatric Drugs
[Springer Nature]
日期:2021-08-22
卷期号:23 (5): 485-497
被引量:4
标识
DOI:10.1007/s40272-021-00467-x
摘要
The outcomes associated with pediatric acute myeloid leukemia (AML) have improved over the last few decades, with the implementation of intensive chemotherapy, hematopoietic stem cell transplant, and improved supportive care. However, even with intensive therapy and the use of HSCT, both of which carry significant risks of short- and long-term side effects, approximately 30% of children are not able to be cured. The characterization of AML in pediatrics has evolved over time and it currently involves use of a variety of diagnostic tools, including flow cytometry and comprehensive genomic sequencing. Given the adverse effects of chemotherapy and the need for additional therapeutic options to improve outcomes in these patients, the genomic and molecular architecture is being utilized to inform selection of targeted therapies in pediatric AML. This review provides a summary of current, targeted therapy options in pediatric AML.
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