抗菌剂
化学
异香豆素
细菌
根际
真菌
异香豆素类
乙酸乙酯
碳-13核磁共振
质子核磁共振
分离(微生物学)
立体化学
有机化学
微生物学
生物
植物
催化作用
遗传学
作者
Fang Miao,Yang Rui,Dongdong Chen,Ying Wang,Baofu Qin,Xin‐Juan Yang,Le Zhou
出处
期刊:Molecules
[Multidisciplinary Digital Publishing Institute]
日期:2012-11-28
卷期号:17 (12): 14091-14098
被引量:41
标识
DOI:10.3390/molecules171214091
摘要
From the ethyl acetate extract of the culture broth of Talaromyces verruculosus, a rhizosphere fungus of Stellera chamaejasme L., (−)-8-hydroxy-3-(4-hydroxypentyl)-3,4-dihydroisocoumarin (1) and (E)-3-(2,5-dioxo-3-(propan-2-ylidene)pyrrolidin-1-yl)acrylic acid (2) were isolated and evaluated for their antimicrobial activities. Their structures were elucidated by UV, IR, MS, 1H-NMR, 13C-NMR and 2D NMR spectra. Compound 1 exhibited the significant activities in vitro against two strains of bacteria and four strains of fungi. Compound 2 gave slight activities on the fungi at 100 µg mL−1, but no activities on the bacteria. Compound 1 should be considered as a new lead or model compound to develop new isocoumarin antimicrobial agents.
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