斑马鱼
多巴胺能
达尼奥
神经科学
儿茶酚胺能
生物
脊椎动物
多巴胺
脊髓
帕金森病
儿茶酚胺能细胞群
疾病
基因
遗传学
内科学
医学
作者
Jörn Schweitzer,Heiko Löhr,Alida Filippi,Wolfgang Driever
摘要
Abstract Dopaminergic and noradrenergic neurons constitute some of the major far projecting systems in the vertebrate brain and spinal cord that modulate the activity of circuits controlling a broad range of behaviors. Degeneration or dysfunction of dopaminergic neurons has also been linked to a number of neurological and psychiatric disorders, including Parkinson's disease. Zebrafish ( Danio rerio ) have emerged over the past two decades into a major genetic vertebrate model system, and thus contributed to a better understanding of developmental mechanisms controlling dopaminergic neuron specification and axonogenesis. In this review, we want to focus on conserved and dynamic aspects of the different catecholaminergic systems, which may help to evaluate the zebrafish as a model for dopaminergic and noradrenergic cellular specification and circuit function as well as biomedical aspects of catecholamine systems. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 72: 256–268, 2012
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