Metabolism, Nutrition, and Redox Signaling of Hydroxyproline

Interorgan metabolism of hydroxyproline (including synthesis, catabolism, and flux) in animals must be quantified using isotope technologies. Efforts should also be directed toward studying dietary, hormonal, and epigenetic regulation of OH-POX expression at transcriptional and translational levels. Another emerging research need is to understand the roles of cellular redox and signaling networks involving both ROS and Δ¹-pyrroline-3-hydroxy-5-carboxylate in nutrition, health, and disease.