大蒜素
偶氮甲烷
癌变
细胞凋亡
体内
结直肠癌
车站3
癌症研究
化学
信号转导
药理学
癌症
生物
生物化学
医学
内科学
基因
生物技术
作者
Xiang Li,Jiahui Ni,Yixin Tang,Xu Wang,Huanhuan Tang,Haidong Li,Sulin Zhang,X. Y. Shen
标识
DOI:10.1080/14786419.2018.1465425
摘要
Allicin is the major biologically active compounds of freshly crushed garlic. It has been reported to inhibit the proliferation and promote the apoptosis of multiple colorectal cancer cells. However, the anti-colorectal cancer effect of Allicin has not been verified by in vivo studies. In the present study, we investigated the effect of Allicin on azoxymethane/dextran sodium sulfate (AOM/DSS) colorectal cancer mouse model and explore the underlying possible mechanism. Our result showed that Allicin could inhibit colonic tumorigenesis of AOM/DSS mice in vivo. In vitro study showed that Allicin promoted the apoptosis and suppressed the survival and proliferation of HCT116 cells. The molecular mechanism is related to the suppression of STAT3 signaling activation. Thus, our data provide further support for Allicin as a potential favorable supplement for human colorectal cancer.
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