AOP-Guided Toxicogenomic Mapping Profiles for Mechanism-Informed Toxicity Pattern Prediction in Zebrafish

experiments. The individual-level effects predicted through AOP-CTMP showed strong consistency with actual observed toxicity patterns, confirming the reliability and practical potential of this approach. The results underscore that AOP-CTMP, enabling prediction of toxicity patterns from chemical perturbations, offers a novel and systematic strategy for key effects identification during toxicity screening.