The ultrasonic extraction conditions of polyphenols from pineapple peel were studied.The factors influencing extraction rate of polyphenols were investigated by single factor and orthogonal tests.The optimal conditions for polyphenols extraction were determined as: 60% ethanol,extraction temperature 45℃,extraction power 200W,extraction time 60min,and the ratio of solution and raw material 15.0∶1.0.Under above conditions,the extraction rate of polyphenols reached 18.48g/kg.