二价
化学
镁
离子
无机化学
生物物理学
生物
有机化学
作者
Martina Kurejová,M Pavlovicová,Ľubica Lacinová
出处
期刊:PubMed
日期:2007-09-01
卷期号:26 (3): 234-9
被引量:3
摘要
We have investigated the permeability of the Cav3.1 channel for Ca2+ and different monovalent cations and the block of the currents by Mg2+ ions. In the absence of extracellular divalent cations, the Cav3.1 channel was more permeable for Na+ than for Cs+ and impermeable for NMDG+. Monovalent currents were inhibited by Mg2+ of near physiological concentration by three orders of magnitude more effectively than the Ca2+ current. Inhibition of outward, but not inward current by Mg2+ was voltage-dependent. Furthermore, magnesium slowed down channel deactivation presumably by interacting with an open channel state.
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