[Relationship between interleukin-6 gene polymorphism and coronary heart disease and its effect on plasma lipid levels].

Objective To study the relationship b et ween interleukin6 (IL6) gene promoter572 C /G and 634 C/G polymorphism and coronary heart disease (CHD) and t he influ ence of IL6 gene polymorphism on plasma lipid and lipoprotein levels . Methods Polymerase chain reaction——restriction fragment length polymorphism (PCRC RFLP) was used for the detection of IL6 genotype in 165 pati ents with CHD and 170 healthy persons. The plasma lipid and li poprotein levels were measured by routine method. Results Plasma to tal cholesterol (TC), triglyceride (TG) and low density lipoprotein c holesterol (LDLC) of the patients with CHD were s ignificantly higher than those of the controls (all P0.05). The distributi ons of IL6 gene 634 C/G polymorphism were not different between CHD group and control group (P0.05), but the IL6 gene 572 C/G polymorphism was significantly diff er ent between them (P0.05). The relative risk of CHD of C allele was 1. 652 times to the G allele 〔odds ratio(OR)=1.652, 95% confidence interva l ( CI): 1.1372.401〕. The level of plasma lipid in G allele carr iers was signi ficantly higher than non-carriers (P0.05). Conclusion IL6 gene 572 C/G polymorphism is associated with CHD, and G allele is an important genetic mar ker. IL6 gene polymorphism may affect CHD through elevation of plasma lipid and lipoprotein levels.