Research Progress on Toll-like Receptor 4 and Tumor

Toll-like receptors is a group of pattern recognition receptors which are found in the recent years. TLR4 is one of hot topics among the 11 TLR members which have been identifited. Activated TLR4 midiates signal transduction pathway via MyD88 and mitogen activated protein, then induces immune response. TLR4 is expressed in a verity of tumors. TLR4 can promote inflammation and the development and progression of tumor via different signal pathway. TLR4 plays an important role in the cancer pain and immune escape. TLR4 may become a new target for cancer biotherapy.