医学
血管生成
新生血管
癌症研究
遗传增强
炎症
血管内皮生长因子
作者
Bieke Van der Veken,Guido R.Y. De Meyer,Wim Martinet
标识
DOI:10.1080/14728222.2016.1186650
摘要
ABSTRACTIntroduction: Atherosclerosis is a lipid-driven inflammatory process with a tremendously high mortality due to acute cardiac events. There is an emerging need for new therapies to stabilize atherosclerotic lesions. Growing evidence suggests that intraplaque (IP) neovascularisation and IP hemorrhages are important contributors to plaque instability.Areas covered: Neovascularization is a complex process that involves different growth factors and inflammatory mediators of which their individual significance in atherosclerosis remains poorly understood. This review discusses different aspects of IP neovascularization in atherosclerosis including the potential treatment opportunities to stabilize advanced plaques. Furthermore, we highlight the development of accurate and feasible in vivo imaging modalities for IP neovascularization to prevent acute events.Expert opinion: Although lack of a valuable animal model of IP neovascularization impeded the investigation of a causal and straightforward link betw...
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