腺苷
抗癌药
药理学
药品
药物发现
医学
化学
计算生物学
生物
生物化学
作者
Shuli Man,Yingying Lu,Lei Yin,X. Cheng
标识
DOI:10.1016/j.drudis.2021.02.020
摘要
In recent years, many studies have shown that adenosine has efficacy for treating cancer. More importantly, some adenosine analogs have been successfully marketed to fulfill anticancer purposes. In this review, we summarize the anticancer effects of adenosine and its analogs in clinical trials and preclinical studies, with focus on their anticancer mechanisms. In addition, we link the anticancer activities of adenosine analogs with their structures through structure-activity relationship (SAR) analysis, and highlight additional promising anticancer drug candidates. We hope that this review will be of help in understanding the importance of adenosine and its analogs with anticancer activities and directing future research and development of such compounds.
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