Progress in the management of chronic GVHD insights into novel therapies to treat and manage GVHD lasting longer than 12 Months

Chronic graft-versus-host disease (cGVHD) is a major cause of poor outcomes after hematopoietic stem cell transplantation (HCT). An increased understanding of the pathobiology of cGVHD has led to the development of novel therapies. This review summarized the underlying pathogenesis of cGVHD and has provided considerations for integrating new agents into practice.