痛风
高尿酸血症
医学
疾病
病因学
尿酸
代谢综合征
观察研究
重症监护医学
内科学
因果关系(物理学)
肥胖
量子力学
物理
作者
Mats Dehlin,Meliha C Kapetanovic,Anna Svärd,Kristina Bengtsson Boström,Per Wändell,Valgerður Sigurðardóttir,Helena Forsblad-d’Elia,Lennart Jacobsson
出处
期刊:PubMed
日期:2020-08-25
卷期号:117
摘要
Hyperuricemia (HU) and gout are strongly associated with CVD, associations that are most likely due to shared etiologies rather than causality. HU is for example causally related to the metabolic syndrome and in particular to obesity. Gout and HU can both be caused by and lead to decreased kidney function. On the other hand, there are observational data suggesting that HU may protect against neurodegenerative diseases such as Alzheimer and Parkinson's disease. Ongoing RCTs with urate and urate lowering therapy (ULT) will help to resolve some of these controversies. Nevertheless, gout is a "curable disease" by ULT, a treatment which in adequate doses may also have positive effect on several associated co-morbidities.
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