医学
肺不张
麻醉
围手术期
腹部外科
通风(建筑)
机械通风
随机对照试验
吸入氧分数
肺
外科
内科学
机械工程
工程类
作者
Xuefei Li,Dan Jiang,Yu-Lian Jiang,Hong Yu,Jia-Li Jiang,Leilei He,Xiaoyun Yang,Hai Yu
出处
期刊:Trials
[Springer Nature]
日期:2019-11-01
卷期号:20 (1)
被引量:7
标识
DOI:10.1186/s13063-019-3668-x
摘要
Abstract Background Postoperative pulmonary complications (PPCs) are the most common perioperative complications following surgical site infection (SSI). They prolong the hospital stay and increase health care costs. A lung-protective ventilation strategy is considered better practice in abdominal surgery to prevent PPCs. However, the role of the inspiratory oxygen fraction (FiO 2 ) in the strategy remains disputed. Previous trials have focused on reducing SSI by increasing the inhaled oxygen concentration but higher FiO 2 (80%) was found to be associated with a greater incidence of atelectasis and mortality in recent research. The trial aims at evaluating the effect of different FiO 2 added to the lung-protective ventilation strategy on the incidence of PPCs during general anesthesia for abdominal surgery. Methods and design PROtective Ventilation with a low versus high Inspiratory Oxygen fraction trial (PROVIO) is a single-center, prospective, randomized controlled trial planning to recruit 252 patients undergoing abdominal surgery lasting for at least 2 h. The patients will be randomly assigned to (1) a low-FiO 2 (30% FiO 2 ) group and (2) a high-FiO 2 (80% FiO 2 ) group in the lung-protective ventilation strategy. The primary outcome of the study is the occurrence of PPCs within the postoperative 7 days. Secondary outcomes include the severity grade of PPCs, the occurrence of postoperative extrapulmonary complications and all-cause mortality within the postoperative 7 and 30 days. Discussion The PROVIO trial assesses the effect of low versus high FiO 2 added to a lung-protective ventilation strategy on PPCs for abdominal surgery patients and the results should provide practical approaches to intraoperative oxygen management. Trial registration www.ChiCTR.org.cn , identifier: ChiCTR18 00014901 . Registered on 13 February 2018.
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