香芹酮
单萜
药理学
作用机理
抗真菌
化学
抗菌剂
传统医学
生物
生物化学
医学
精油
体外
微生物学
植物
柠檬烯
作者
Abdelhakim Bouyahya,Hamza Mechchate,Taoufiq Benali,Rokia Ghchime,Slim Charfi,Abdelaali Balahbib,Pavel Burkov,Mohammad Ali Shariati,José M. Lorenzo,Nasreddine El Omari
出处
期刊:Biomolecules
[MDPI AG]
日期:2021-12-01
卷期号:11 (12): 1803-1803
被引量:45
摘要
Carvone is a monoterpene ketone contained in the essential oils of several aromatic and medicinal plants of the Lamiaceae and Asteraceae families. From aromatic plants, this monoterpene is secreted at different concentrations depending on the species, the parts used, and the extraction methods. Currently, pharmacological investigations showed that carvone exhibits multiple pharmacological properties such as antibacterial, antifungal, antiparasitic, antineuraminidase, antioxidant, anti-inflammatory, and anticancer activities. These studies were carried out in vitro and in vivo and involved a great deal of knowledge on the mechanisms of action. Indeed, the antimicrobial effects are related to the action of carvone on the cell membrane and to ultrastructural changes, while the anti-inflammatory, antidiabetic, and anticancer effects involve the action on cellular and molecular targets such as inducing of apoptosis, autophagy, and senescence. With its multiple mechanisms, carvone can be considered as natural compounds to develop therapeutic drugs. However, other investigations regarding its precise mechanisms of action as well as its acute and chronic toxicities are needed to validate its applications. Therefore, this review discusses the principal studies investigating the pharmacological properties of carvone, and the mechanism of action underlying some of these properties. Moreover, further investigations of major pharmacodynamic and pharmacokinetic studies were also suggested.
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