肝细胞癌
重编程
癌症研究
血管内皮生长因子受体
生物
免疫系统
血管生成
癌症
机制(生物学)
肿瘤微环境
透视图(图形)
医学
免疫学
免疫疗法
作者
Sin Chi Chew,Si Ying Choo,Pierce K. H. Chow
标识
DOI:10.1038/s41416-021-01286-0
摘要
We found a shared immunosuppressive microenvironment between foetal liver and hepatocellular carcinoma (HCC) which includes the re-emergence of foetal-associated endothelial cells (PLVAP/VEGFR2) and foetal-like (FOLR2) tumour-associated macrophages in HCC, mediated via VEGF-NOTCH signalling. The discoveries suggest possible novel targets for therapeutic interventions in HCC.
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