齿合度
化学
脱质子化
配体(生物化学)
金属
一元酸
螯合作用
密度泛函理论
水溶液中的金属离子
分子
结晶学
无机化学
离子
计算化学
高分子化学
有机化学
生物化学
受体
标识
DOI:10.1016/j.inoche.2022.109634
摘要
The Fe(III), Co(II) and Cu(II) complexes of three azo compounds namely, 2-(phenylazo)-1-naphtllol (Sudan I) (HL1) a, 4-(phenylazo)-1-naphthol (HL2) b and 2,4-bis(phenylazo)-1-naphthol (HL3) c were prepared and characterized on the basis of their elemental analysis, molar conductance, UV–VIS and FT IR spectroscopic studies. Besides, density functional theory (DFT) computations were conducted to study structures and energetics of the ligands and their complexes. Molecular Electrostatic Potential was also calculated by the DFT method and predicts the most reactive part in the molecule. The isolated complexes are found to have the formulas [Cu(L1)2] a1, [Co(L1)2] a2, [Fe(L1)3] a3, [Cu(HL2)2Cl2].H2O b1, [Co(HL2)(NO3)2].H2O b2, [Fe(HL2)Cl3].H2O b3, [Cu(HL3)Cl2].H2O c1, [Co(HL3)(NO3)2].H2O c2 and [Fe(HL3)Cl3].H2O c3. The IR result showed that the ligand a was chelated with the metal ions in a monobasic bidentate manner, with NO donor sites of the azo nitrogen and the deprotonated phenolic oxygen. While the ligand c was chelated with the metal centers in a neutral bidentate manner and the ligand b was bound with the metal ions as a neutral monodentate donor by azo nitrogen atom. The molecular docking results indicated that the ligands HL1 a, HL2 b and HL3 c may possess significant anti-inflammatory activity. Gamma irradiation of variable concentrations of the ligand solutions HL1 a and its complexes [Cu(L1)2] a1, [Co(L1)2] a2 and [Fe(L1)3] a3 was investigated. The color bleaching of the dyes solutions was increase gradually with increasing absorbed dose in the dose range of 3, 5 and 10 kGy.
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