甾醇调节元件结合蛋白
甘油三酯
脂肪酸合酶
化学
下调和上调
信使核糖核酸
内分泌学
内科学
CD36
受体
甾醇
脂质代谢
生物化学
生物
胆固醇
基因
医学
作者
Linfang Li,Xiaoyi Zhang,Hangjiang Ren,Xiuqing Huang,Tao Shen,Weiqing Tang,Lin Dou,Jian Li
摘要
miR-23a-3p and miR-23b-3p are members of the miR-23~27~24-2 superfamily. The role of miR-23a/b-3p in regulating hepatic lipid accumulation is still unknown. Here, we found that increased miR-23a-3p and miR-23b-3p levels were accompanied by an increase in the protein levels of the sterol regulatory element-binding protein-1 (SREBP-1) and fatty acid synthase (FAS) in the steatotic livers of mice fed a high-fat diet and leptin receptor-deficient type 2 diabetic mice (db/db). Importantly, overexpression of miR-23a/b-3p in Hep1-6 cells elevated the intracellular triglyceride level and upregulated the expression of Srebp-1c and Fas. Taken together, these results suggested that miR-23a/b-3p enhanced mRNA stability by binding the 5'-UTR of Srebp-1c and Fas mRNA, thereby promoting triglyceride accumulation in hepatocytes.
科研通智能强力驱动
Strongly Powered by AbleSci AI