吡那考
化学
芳基
硼酸
硅胶
铃木反应
苯硼酸
有机化学
组合化学
催化作用
烷基
作者
Naoki Oka,Tsuyoshi Yamada,Hironao Sajiki,Shuji Akai,Takashi Ikawa
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-05-02
卷期号:24 (19): 3510-3514
被引量:21
标识
DOI:10.1021/acs.orglett.2c01174
摘要
A wide range of aryl boronic 1,1,2,2-tetraethylethylene glycol esters [ArB(Epin)s] were readily synthesized. Purifying aryl boronic esters by conventional silica gel chromatography is generally challenging; however, these introduced derivatives are easily purified on silica gel and isolated in excellent yields. We subjected the purified ArB(Epin) to Suzuki-Miyaura couplings, which provided higher yields of the desired biaryl products than those obtained using the corresponding aryl boronic acids or pinacol esters.
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