谷胱甘肽
海马结构
氧化应激
海马体
发病机制
体内
人口
化学
认知功能衰退
神经科学
抗氧化剂
内分泌学
内科学
生物化学
医学
疾病
生物
痴呆
酶
遗传学
环境卫生
作者
Pravat K. Mandal,Divya Dwivedi,Deepika Shukla,Avantika Samkaria,Rimil Guha Roy,Yashika Arora,Komal Jindal
摘要
Oxidative stress (OS) is a critical factor in the pathogenesis of Alzheimer's disease (AD). Elevated OS in AD lowers the level of glutathione (GSH), a brain antioxidant. Currently, GSH is under examination in the clinical population for understanding its association with oxidative load in AD research. Significant depletion in hippocampal GSH, as observed using in vivo magnetic resonance spectroscopy (MRS), reportedly correlates with cognitive impairment in AD. Alterations in cellular-energy metabolism and increased hippocampal pH have also been reported in AD. Hence, this combined molecular interplay between hippocampal GSH and pH must be studied longitudinally for advancing AD research. Herein, we propose a schematic model depicting the molecular events in AD pathogenesis and provide a possible link between OS, GSH depletion, and pH alterations in the hippocampus. The model would further potentiate the need for in vivo longitudinal studies to confirm the interlinked mechanism between OS, hippocampal GSH depletion, and pH increment in an AD patient brain.
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