光动力疗法
光敏剂
硝基还原酶
聚集诱导发射
荧光
活性氧
化学
生物物理学
缺氧(环境)
光化学
肿瘤微环境
癌症研究
氧气
生物化学
医学
肿瘤细胞
生物
前药
有机化学
物理
量子力学
作者
Shi Jizhong,Zhencao Wang,Chaojie Shen,Tingting Pan,Longteng Xie,Mintao Xie,Lijiang Huang,Yongsheng Jiang,Jianmin Zhang,Wei Zuo,Zu-Sheng Huang
标识
DOI:10.1016/j.dyepig.2022.110122
摘要
Photodynamic therapy (PDT) is a promising treatment for cancer, but still faces challenges. For example, the residual photosensitizers (PSs) can cause toxic effects on normal tissues. Thus, it is of great importance to change the PS into safe compounds in or after PDT process. In this work, a novel PS NTPy was synthesized and successfully applied for cancer therapy. NTPy with aggregation-induced emission (AIE) characteristics shows high reactive oxygen species generation efficiency and exhibits a strong fluorescence emission in 678 nm. In addition, NTPy shows excellent mitochondria targeting capacity. In hypoxic microenvironment, NTPy is degraded into TPy via the reduction caused by nitroreductase. TPy shows very little PDT activities and low fluorescence emission. Therefore, NTPy can detect the hypoxic microenvironment of tumor through fluorescence “turn-off” response. More importantly, NTPy can reduce the side effects of PS on normal tissues after effective PDT treatment. This work provides a new strategy for intelligent PDT treatment and increases the biological safety of PDT.
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