Occupational Health and Safety Aspects ofADCsand Their Toxic Payloads

Antibody–drug conjugates (ADCs)provide a promising technology platform for the treatment of various cancers and other diseases. Although these new therapies ideally deliver treatment directly to their target, their manufacture involves the handling of highly potent and hazardous substances. This chapter presents a review of the background of ADCs and will discuss the inherent hazards associated with their individual components. A discussion on how these hazards are evaluated and how the exposure potential to workers is determined will follow. Finally, measures to control and contain these highly potent compounds will be described along with methods for verifying the efficacy of these controls.