肌生成抑制素
生物
舌头
脾脏
信使核糖核酸
内科学
突变体
卵泡抑素
内分泌学
骨骼肌
基因
病理
医学
免疫学
遗传学
作者
Zhao‐Bo Luo,Qi‐Rong Luo,Mei‐Fu Xuan,Sheng-Zhong Han,Junxia Wang,Qing Guo,Yong Gyu Choe,Song‐Shan Jin,Jin‐Dan Kang,Xi‐Jun Yin
摘要
Abstract BACKGROUND Myostatin ( MSTN ) negatively regulates skeletal muscle development; however, its functions in internal organs have not been thoroughly investigated. Here, we compared the morphological, molecular, and biological characteristics of the heart, liver, spleen, lungs, kidneys, and tongue of homozygous MSTN mutant (MSTN −/− ), heterozygous MSTN mutant (MSTN +/− ), and wild‐type (WT) piglets. RESULTS The heart and liver were lighter in MSTN −/− piglets than in MSTN +/− piglets, while the tongue was heavier in MSTN −/− piglets than in WT piglets ( P < 0.05). Furthermore, the tongue was longer in MSTN −/− piglets than in WT piglets, and myofibers of the tongue were significantly larger in the former piglets than in the latter ones ( P < 0.01). mRNA expression of MSTN in all organs was significantly lower in MSTN −/− and MSTN +/− piglets than in WT piglets ( P < 0.05). Meanwhile, mRNA expression of follistatin, which is closely related to MSTN, in the heart and liver was significantly higher in MSTN −/− piglets than in MSTN +/− and WT piglets ( P < 0.05). In addition, protein expression of MSTN in the heart, kidneys, and tongue was significantly lower in MSTN −/− piglets than in WT piglets ( P < 0.01). CONCLUSION These results suggest that MSTN is widely expressed and has marked effects in multiple internal organs. Myostatin has crucial functions in regulating internal organ size, especially the tongue. © 2019 Society of Chemical Industry
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