微泡
免疫球蛋白E
免疫学
过敏反应
脱颗粒
组胺
肥大细胞
抗体
过敏
受体
化学
细胞生物学
生物
医学
内科学
生物化学
基因
小RNA
作者
Hae Woong Choi,Jutamas Suwanpradid,Il Kim,Herman F. Staats,Muzlifah Haniffa,Amanda S. MacLeod,Soman N. Abraham
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2018-11-09
卷期号:362 (6415)
被引量:48
标识
DOI:10.1126/science.aao0666
摘要
Dendritic cells give mast cells a nudge Anaphylaxis is a life-threatening allergic reaction triggered after antigen-specific immunoglobulin E (IgE) antibodies bind to target allergens. These antibodies then cross-link IgE-specific Fc receptors on the surface of mast cells. The mast cells rapidly release inflammatory mediators, including histamine, resulting in smooth muscle contraction, vasodilation, and blood vessel leakage. Because mast cells are usually found in the perivascular abluminal surface of blood vessels, it has been unclear how blood-borne allergens can interact with them. Choi et al. used live intravital imaging of the mouse vasculature to show that a specialized subset of dendritic cells sample blood-borne antigens and relay them to mast cells on the surface of microvesicles (see the Perspective by Levi-Schaffer and Scheffel). IgE-bound mast cells then vigorously degranulate after contact with these microvesicles. Science , this issue p. eaao0666 ; see also p. 640
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